The only thing you need to do while recording is to remember to record-enable all the tracks you’d like to record at the same time. It really won’t add to the magic of recording keyboard and vocals at the same time if it stresses you out more than anything. They’ll be fine once they’re recorded, but the whole point is to “live” your performance.
If you’ll be using USB audio interfaces, you may have difficulty getting your tracks to “sync”. It’s an independent process and has resulted in some of the lowest audio latency rates we’ve ever heard! The difference with Thunderbolt is that it writes data directly to the storage medium without passing through the CPU.